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Hair Loss as a Side Effect of Lamotrigine Treatment

July 31, 2006

To the Editor: Lamotrigine is an established and usually well tolerated treatment for bipolar disorder. Adverse effects of the drug may include serious toxic epidermal necrolysis, in which alopecia is a well known phenomenon (1). However, apart from occurring as a part of epidermal necrolysis, hair loss is usually not associated with lamotrigine treatment in the literature (2).

“Mrs. G,” a 63-year-old woman, was treated as an inpatient from Aug. to Sept. 2003 because of a depressive episode from a previously diagnosed bipolar disorder. During hospitalization, therapy with lamotrigine was started, and the dose was later increased in an ambulant setting up to 150 mg daily. After her discharge, Mrs. G was visited regularly by the psychiatric ambulance. During this entire period, she did not receive any other pharmaceutical treatment except eye drops containing hypromellose. She reported an increase in hair loss 2 to 3 weeks after beginning lamotrigine treatment. The hemogram and other laboratory parameters did not show pathological findings. The result of the trichogram, a classical hair root examination made by an external consultant dermatologist in Nov. 2003, showed an increase of resting (telogen) and dystrophic hair at the expense of growing (anagen) hair. The hair loss was mainly located in the area of the temporal bone, which is characteristic for pharmacologically induced alopecia (3, 4).

Because of the probable association of the reported alopecia with lamotrigine treatment, the treatment was discontinued, which resulted in a rapid regression of hair loss.

Hair loss has been reported as a rare side effect of lamotrigine treatment in the German Summary of Product Characteristics. However, in the literature (using MEDLINE, PubMed, ISIweb, and Embase research) we only found one case report suggesting a possible link between hair loss and lamotrigine treatment (5). Patrizi and colleagues reported a case of a patient who was treated with a combination of magnesium valproate and lamotrigine and suffered from hair loss. The authors indicate that the hair loss in their patient may have been caused by the intake of magnesium valproate (5).

To our knowledge, our case is the first report of a causal connection between lamotrigine intake and alopecia. Our patient had not been treated with medications other than lamotrigine, and the pathology vanished after discontinuation of the drug, which makes a coincidence unlikely. Patients and clinicians should be aware of alopecia as a possible rare side effect of lamotrigine treatment.

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Friends, family mourn loss of 2005 SHS grad

July 28, 2006

Valerie Jimenez, a 19-year-old Selma native, was killed July 18 on Highway 99 south of Fresno when her car ran into the back of a big rig.

Jimenez was driving to Selma from Fresno to meet some of her friends for the evening when, for an unknown reason, she failed to slow down and crashed into the rear of the big rig, the California Highway Patrol reported.

She was in the number two lane traveling at about 65 mph southbound on the 99 in a 2003 Honda Civic. Due to the evening road construction, the traffic had been reduced to stop-and-go traffic. The big rig driven in front of her by Francisco Pineda, 44, was traveling at about two or three mph. Pineda, of Galt, was not injured, and neither were his passengers, Michelle Pineda, 39, and Augustine Pineda, 5.

The number two and number three lanes were closed 300 feet south of the accident due to Caltrans lane closures that have been a nightly occurrence as the highway is being widened and repaved. The accident occurred just north of the Central Avenue exit.

Reportedly, Jimenez braked at the last minute but was unable to stop in time and hit the DOT bar meant to stop cars from traveling all the way underneath the carriage of the trailer. She was declared dead at the scene.

Friends and family describe the 2005 graduate of Selma High School as an outgoing and fun girl with a bubbly personality, perfect for the cheerleading squad she was a part of. Along with cheering at Selma High School, Jimenez was a volunteer coach for the Selma Bandit Youth Cheer program run by the city.

“The little girls all loved her,” Icee Story-Ruiz, who was a high school friend and fellow cheer coach, said of the girls Jimenez coached. “They would be all over her all the time and always copied her.”

Story-Ruiz and Jimenez met in Mrs. Augurie’s fifth grade class at Roosevelt Elementary School and cheered together throughout high school until their graduation in 2005.

“I remember her coming to school and everybody was like ‘Do you see her hair?’” Story-Ruiz said of her friend’s well-known hairdo.

Jimenez kept herself busy all throughout high school as a part of the cheer squad, the soccer team and leadership. She ran for Associated Student Body President at almost every chance she could get and was the Prom Princess her junior year. Another one of her gladly accepted duties was performing the daily bulletin every morning with her friend Jared Davis.

“Everyone heard her voice the first time in the morning,” Davis said.

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Davis originally met Jimenez in their freshman year agriculture class where he said she wore her farmers hat whenever they planted during the class period.

After graduating from Selma High School Jimenez took on numerous jobs, summer school and a full load at Fresno City College. She was always working at someplace new. Although her main job was at Bed Bath and Beyond in Fresno, she had also worked as a secretary, at a Mexican food restaurant, at Denny’s as a hostess, at Mervyn’s and the JC Penney’s here in Selma.

“She loved job hopping,” her roommate and long-time friend Lea Perez said. “She would always get the newspaper and look for jobs and I was like, ‘Valerie, you already have a job.’”

Jimenez hoped to attend University of California, Davis as a nursing major, or to follow her favorite hobby and become a fashion designer. Perez commented that Jimenez had decorated their entire apartment, all with homemade items. Her next door neighbor while growing up, Tori Munoz, remembered a time when she went to check on her friend because the power had gone out. She found Jimenez sitting there in the dark sewing sequins to her shoes.

“She wanted her own boutique,” Davis said. “That was her first dream.”

Her boyfriend of over three years, Benjamin Rodela, says he’ll most remember her “annoying laugh.” He had been expecting to see her on Tuesday night, but her mother, Judy, called him late that night to tell him of the accident.

Amongst the disbelief, friends and family, including her younger brother Marcus and younger sister Brianna, rallied together to organize a car wash held in her honor on Saturday at the Mobile Gas near Del Taco. From 8 a.m. to around 2:30 p.m. in the sweltering heat, the donation car wash made over $4,000 and also received donations from Wal Mart. Her family, with members ranging from Selma to Caruthers and Fresno, was granted use of the Portuguese Hall for a reception following her service.

Her rosary will be recited on Wednesday at 7 p.m. at St. Joseph’s Catholic Church, with viewing the hour before. The mass will be given on Thursday at 9 a.m. also at St. Joseph’s Catholic Church. Her burial will follow at Floral Memorial Park.

She was described as the lovable girl like no other. “Every memory was worth it with her,” Davis said of his friend.

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Exercise as therapy

July 24, 2006

With state-of-the-art exercise equipment, a physical therapy center, a full-service day spa, and child-care center, it would be difficult to imagine how to improve The Firm Health Club. The new owners of health club, located at 1301 W. University Ave., have ambitious plans to introduce new services, improve customer service and will reaching out to the community by sponsoring health-related events.

The former CEO and owner of the health club, Drew Friend, sold the club recently to a partnership of Flagstaff locals, all who work in health care or the fitness industry. Friend helped design the facility, which opened in the spring of 2000.

A partial list of the new owners includes the former manager of The Firm, Bruce Hutchinson, and several members of DeRosa Physical Therapy, which has a satellite office inside the health club. While the health club will be renamed Summit Health & Fitness, but the Black Diamond Spa, which has a reputation for its upscale body and beauty treatments, will keep its name.

The new name for the health club is intended to coincide with a closer working relationship with Summit Center, a comprehensive orthopedic care facility in Flagstaff. Owners say the relationship will allow the fitness center become the premier health club in Flagstaff, offering access to state-of-the-art exercise equipment to physical therapy patients and new exercise programs at the health club that go beyond the standard staples of yoga classes and cardio routines.

An example would be a cancer fit program, which would be tailored to cancer survivors to help them stay in the best of health. The program would evaluate cancer survivors and establish a specific exercise routine and diets geared to their exact nutritional needs.

Hutchinson said he has personally seen how these programs can extend the lives of cancer survivors and patients alike, simple by adding a targeted exercise regime and sensible diet program.

The Black Diamond Spa will also expand its community outreach, hosting or sponsoring fund-raisers for non-profits, mostly related to health care or fitness.

It recently sponsored an event collecting hair for Locks of Love, a non-profit organization that provides hairpieces to financially disadvantaged children suffering from long-term medical hair loss. Hutchinson said when the new owners bought the business from Friend, the purchase includes the building and the land it sits on which could allow the future expansion of the facility. He said there are no current plans to expand the size of the health club.

The are a variety of memberships of to the club, with individual plans starting at $49 and family plans starting at $80. Hutchinson said more than 40 businesses have corporate accounts with club, offering discounted memberships to the business.

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Female hair loss not so rare

July 19, 2006

Cheryl Brewster was the envy of every gym rat, with her hard body and shoulder-length, sun-kissed locks.

So when her hair began falling out two years ago, the personal trainer was devastated.

“My part was getting wider, I could see more of my scalp and it was no coincidence that clumps of hair were falling out in the shower,” says Brewster, 40, of Orinda.

A slew of vitamins and thickening shampoos later, Brewster’s dermatologist diagnosed her with female-pattern baldness and started her on Rogaine — the drug minoxidil — which initially caused Brewster to shed more hair. It is only recently, after a year of use, that Brewster is seeing regrowth.

“I was horrified,” recalls Brewster, who went on anti-depressants. “I didn’t want to be the trainer with the bald head.”

It’s likely that stress and anemia exacerbated Brewster’s genetic condition. In fact, there are endless triggers for the millions of women who suffer from hair loss — from medications and crash dieting to thyroid problems and autoimmune disorders, says Alexander Lewis, a Walnut Creek dermatologist. Millions more suffer from traction alopecia, a hair-loss epidemic caused by cornrow braids and other tight hairstyles.

Unlike male-pattern baldness, which is triggered by a known hormone, women with the condition often find themselves on a frustrating journey with more dead-ends than answers. Often they become depressed, coping with the loss of their crowning glory in a society that favors full, youthful heads of hair. For that reason, many don’t seek help. But a growing online community is now spreading the word on what works and where to get help.

“Women have camouflaged their hair loss for a long time,” says Alan Bauman, a Florida hair transplant surgeon whose clientele is 40 percent female. “But it is definitely coming out of the closet, thanks to new treatments.”

Hair loss is perfectly normal. The average woman sheds 50 to 100 hairs daily, experts say. With age, follicles produce less quality hair, particularly after menopause. Regardless, dermatologists see just as many women in their 30s and 40s as post-menopausal women, says Dr. Lewis, a Stanford University adjunct associate professor of dermatology.

Like most dermatologists, he performs scalp biopsies and blood tests to rule out medical conditions and usually follows with Rogaine, the only medicine known to slow hair loss. Oftentimes, he prescribes the 5 percent intended for men, not the 2 percent for women.

“There was some increased facial hair with the 5 percent, so they took it down to 2,” he says. “But I haven’t seen a lot of that in my practice.”

Many who take it stop too soon because it can cause flaking and some initial shedding. But doctors urge them not to.

“You have to give it at least four months,” says Kelly Hood, a Lafayette dermatologist.

Cortisone treatments usually follow or are used in conjunction with Rogaine. All treatments work the same way: strengthening follicles to prevent further loss and stimulate new growth.

But when your immune system rejects your hair, strengthening is irrelevant.

Miranda Gardner suffers from alopecia areata, an autoimmune disorder that effects 5 million Americans. The body acts like it’s allergic to the hair, pushing it out in large, circular patches. Gardner, of Concord, first noticed it two years ago, shortly after giving birth to her son.

“I started a new job and this girl kept asking me what was wrong with my head,” Gardner recalls. “She thought I had cancer.”

Gardner recalls feeling “cold breezes back there,” but she couldn’t see anything. That night, she used a hand mirror to look at the back of her head. There, she found a bald spot the size of a golf ball.

“I cried for three days,” Gardner says.

A local dermatologist recommended cortisone scalp injections, which were painful and yielded little results. Next, Gardner saw Vera Price, a UCSF dermatologist specializing in hair disorders. Dr. Price put Gardner on cortisone pills, which she finished in May. She has yet to see significant growth.

“Whoever thinks this isn’t a big deal doesn’t know what it’s like to be 19 and have 65 percent of your hair gone,” says Gardner, now 21.

Today, Gardner’s hair covers three softball-sized bald spots. She spends her mornings fanning it out and hair-spraying it down before tying it in a bun. Most of the time she feels hopeless and depressed, she says, and fears even visiting the salon for a trim.

“I told my mom the other day that I don’t know what I’ll do if I lose any more hair,” Gardner says.

Quality, human-hair wigs cost thousands and, like most remedies, aren’t covered by insurance. Despite the debilitating psychological effects of alopecia areata, it is considered a cosmetic issue.

Unfortunately, even hair transplantation surgery is not an option for those with active alopecia areata, because, post-transplant, the body still sees the hair as foreign, and ejects it.

But for women with thinning hair and about $5,000, surgery can yield significant results.

“Ten years ago, the grafting was not microscopic enough for women,” Dr. Bauman says. “Today, the technology is such that we can graft between follicles.”

In other words, the pluggy look is a thing of the past. Surgeons transplant hair from the lower back of the head to the front and crown. Sessions typically run $4,000-$7,000 and most women need one or two sessions, says Dr. Lewis, who also performs transplant surgeries. In the past decade, his female clientele has grown from 1 in 25 to 25 percent of his practice.

Some surgeons, including Bauman, also perform a series of light-based, low laser treatments on patients, which is said to hit metabolic centers of the hair and, through a photochemical reaction, create better-quality hair.

“I see it as a nonchemical minoxidil,” he says.

But, Bauman says, this treatment is best for women who are just starting to thin. He encourages anyone interested in transplantation to research a surgeon’s background. A good source is the International Society of Hair Restoration Surgery at www.ishrs.org.

As with any disease, there are varying degrees of alopecia. Marty Monroe lives with the most severe kind.

The South San Francisco mother of three has alopecia universalis, a rare form of alopecia areata that causes hair loss on the entire body. She was diagnosed with alopecia areata at the age of 8, and by 18, it had advanced to universalis.

“This is the whole enchilada,” says Monroe, who is now 51 and says that humor is what carries her through. “No nose hairs. No underarm hairs.”

When she was little, Monroe’s mother told her it fell out because of nerves. “That’s what they said back then,” she says.

And even though Monroe has traced the autoimmune disorder to her mother’s side, she does believe trauma plays a critical role in hair loss.

For 17 years, she has led a Bay Area support group for alopecia areata sufferers. Sure enough, most of the people she’s met connect their hair loss to a time of severe stress. The death of a loved one. A major life transition.

She gives them all the same piece of advice: “Fake is fabulous. Get a good hairpiece.” Hers is long and brown and wavy.

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Branding Is Key Part of Firm’s Marketing

July 19, 2006

Branding your firm is a crucial part of your overall marketing strategy. Establishing a brand involves defining your company, knowing exactly what niche you serve in your industry and convincing your potential customers that your product or service is the only solution to their problem.

The smaller the enterprise, the more important branding is because small firms tend to have fewer resources and lower marketing budgets.

If you have established a strong brand, you will not have to do as much marketing to have an effect on potential customers.

“The truth is that branding has to occur before any other kind of marketing: advertising, public relations, Web marketing, identity and so forth,” said Rob Frankel, a branding expert and author of “The Revenge of Brand X.”

Once people are aware of your company and are convinced that yours is the only solution for them, they will stop shopping elsewhere.

“The clearer your brand message, the more likely people are to tell others about it, including why it’s the only brand to buy. That’s how you turn users into evangelists. Your advertising, public relations and other marketing efforts run more cost-effectively because the message gets through much more quickly and memorably.

“That’s how branding works,” Frankel said.

Unfortunately, he said, most companies don’t spend much — if any — time on brand strategy development, thinking they’ll do fine if they can just make potential customers aware of their products.

“The result is that they spend five or six times the marketing money on marketing that has no brand strategy, so it simply doesn’t work,” Frankel said.

More information on specific branding strategies, along with case studies, is available free at Frankel’s website, http://www.robfrankel.com .

Getting Your Product Widely Distributed

Q: I’m a former UCLA pharmacologist who has developed and marketed an herbal anti-hair-loss lotion overseas since 1999. But I haven’t been able to get my product distributed widely in the United States. Can you offer some suggestions?

A: Launching a product is a challenging and costly undertaking. However, it’s not impossible.

“Your product could potentially be introduced through several unique venues, giving it multiple opportunities to succeed,” said Dave Lavinsky, president of GrowThink, a Venice marketing firm.

One possibility might be natural food and nutritional supplement stores, such as Whole Foods Market and GNC.

“These are places that traditionally carry supplements and herbal remedies,” Lavinsky said.

A second channel for you would be hair salons and spas.

“Virtually all high-end salons offer select products for sale to their clients,” Lavinsky said. “An herbal anti-hair-loss lotion could be of interest to some of these businesses. Ideally, you should target salons serving an older clientele.”

Another strategy would be for you to target physicians who treat hair loss, such as dermatologists and endocrinologists.

“Ideally, you would want to present doctors with product case studies and statistical findings,” Lavinsky said.

Do some research on hair loss, how many people it affects nationally and what kinds of annual sales figures current products achieve.

Don’t forget about selling your product directly online.

” ‘Hair loss’ is a popular Internet search term,” Lavinsky said. “Over 100,000 people search this term each month on Yahoo alone. Setting up an e-commerce website and advertising [at search engines] on hair-loss-related keywords could bring in a significant flow of buyers.”

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Risks and benefits of the profit motive in the pharmaceutical industry

July 12, 2006

Where do new drugs come from?

In almost any publication that comes from pharmaceutical companies or their associations there will inevitably be a statement that over the past 50 years nearly all new drugs have been discovered by drug companies. Just to reinforce this point, this success is often contrasted with the failure of the formerly socialist countries of central and eastern Europe to produce any important drugs.

The message to readers, in case they have missed the point, is that private enterprise, and private profits, is the best way to get newer and better medications. Governments that threaten to do anything about profit levels should take heed of this reality. Right now, the pharmaceutical industry in the United States and its friends in government are using exactly this line of reasoning to push for an increase in prices in other developed countries such as Canada and those in the European Union. Price controls mean less revenue for the companies; less revenue means fewer dollars for research and developemnt; and inevitably fewer “life saving drugs.� Or so the argument goes.

Like many pronouncements from the pharmaceutical industry this one, about who discovers new drugs, has some element of exaggeration. Fifty out of 77 anticancer drugs, including ones such as Taxol ®, that are approved in the United States were developed with help from the National Cancer Institute. Of the 21 most important drugs introduced in the U.S. between 1965 and 1992, 15 were developed using knowledge and techniques from federally funded research. Of these, research from the National Institutes of Health led to the development of 7 drugs used to treat patients with cancer, AIDS, high blood pressure, depression, herpes and anemia.

Despite the hyperbole that comes out of industry, it is still true that the incentives in a system of private enterprise have contributed to the development of many essential drugs. But that does not mean that the private profit incentive results in unalloyed good, or even that the benefits of using a profit driven system outweigh the inequities it leads to.

Industry priorities in the industrialized and Third World

Consider the new drugs that the industry introduces. Figures from the Patented Medicine Prices Review Board (PMPRB), a federal Canadian organization, show that fewer than 10% of new drugs are breakthrough products or significant advances over existing products. Industry will dispute this assessment on the grounds that the PMPRB classifies drugs for pricing purposes and does not revisit the classification even if drugs prove more important than initially thought. Both of these criticisms are true, but the PMPRB assessments are confirmed by figures from the independent French drug bulletin La revue Préscrire.

Why are companies willing to invest up over $800 (US) million to develop drugs for baldness and allergies or to find the sixth drug in a class for lowering cholesterol? (There is a good deal of controversy about the $800 million figure. Interested readers should look at the exchange of articles between Donald Light and Joe DiMasi in the September 2005 issue of the Journal of Health Economics.) Assuming that the $800 million figure is correct, the simple answer is that in developed countries like Canada, the U.S. and western Europe there are huge markets for these products. Do they represent the best use of billions of dollars and thousands of scientists? By any calculation, the answer is no.

If industry’s priorities are distorted in developed countries this distortion is magnified many fold when it comes to choosing between industrialized and Third World countries. According to a recent article in the British journal The Lancet in the past 30 years out of 1556 new chemical entities launched onto the world market, the number targeting the most neglected diseases (diseases mainly affected people in developing countries) is 10, 18 if malaria is added and 21 if tuberculosis is included.

The Drugs for Neglected Diseases Working Group and the Harvard School of Public Health sent written questionnaires to the world’s top 20 pharmaceutical companies to assess the level of R&D activity in five neglected diseases (sleeping sickness, leishmaniasis, Chagas disease, malaria and tuberculosis). Thirteen companies responded, 11 of which completed the questionnaire. In fiscal 2000, 8 of the 11 spent nothing on R&D for sleeping sickness, leishmaniasis and Chagas disease; only 2 spent anything on malaria research and 7 spent less than 1% of their R&D budgets on any of the five diseases or failed to respond to the question.

Decisions about the allocation of resources-industrialized countries versus Third World countries, areas of high medical need versus areas with large markets-are perfectly reasonable in an industry driven by private profit. If companies chose otherwise then their shareholders would desert them in droves. And that is the problem from the perspective of the health community, consumers and patients. Choices driven by a market economy often do not meet the health needs of society.

The health care team

The industry’s focus on the bottom line also puts the lie to its claim to be part of “the health care team.� True, doctors like me do not work for free, but when there is a conflict between my financial well being and the health of my patients, my patients come first. Not so with drug companies. Companies value their economic health above the health, in a physical sense, of the individuals in society. Vioxx ® is just the most recent example that illustrates the priorities of pharmaceutical companies. For the five years, until it pulled Vioxx off the market, Merck consistently rejected the contention that its drug could increase deaths from cardiovascular causes and stuck to the claim that any differences between Vioxx ® and other traditional nonsteroidal anti-inflammatories were due to the cardiovascular protective effects from these other medications. Merck was unwilling to jettison a drug selling billions of dollars a year until it had no choice.

Put simply, drug companies make a product that can be used to improve people’s health; the same way that construction companies build hospitals that can be used to improve people’s health. Neither are part of a health care team.

Acts of commission: going to court

If the profit motive has driven companies to acts of omission-failure to do research and develop drugs for the Third World, failure to use its resources properly in industrialized countries-it has also produced acts of commission. In an effort to preserve profits in Canada, Bristol Myers Squibb (BMS) took the Canadian Coordinating Office for Health Technology Assessment to court over its report stating that the risk:benefit ratio of all of the statin class of cholesterol lowering drugs was equal. BMS was worried that the report would undercut the market for its statin Pravachol ® In Spain, Merck sued the editor of Bulleti Groc, an independent drug bulletin, over an article it had published highlighting methodological flaws in the VIGOR study on Vioxx ®.

In both instances when the cases reached the courts the judgements went against the companies. However, winning and losing is probably not uppermost in the companies’ minds when they initiate these suites. If companies have protected their drugs for an extra year, as Bristol Myers Squibb did, then that’s another year of larger sales. Merck’s actions likely sent a message to other journals to back off or face a potential costly court battle.

Acts of commission: suppressing and rewriting research

Besides going to court or threatening to go to court, companies take other measures to preserve the sales of their products. GlaxoSmithKline did not publish results that showed that paroxetine (Paxil ®) was ineffective for the treatment of depression in children and adolescents because according to an internal company memo “It would be commercially unacceptable to include a statement that efficacy had not been demonstrated, as this would undermine the profile of paroxetine.� Researchers who knew of the results of these unpublished studies were prevented from speaking publicly because of confidentiality clauses that they had signed.

When companies need to convince doctors of the value of one of their drugs, some turn to ghost writers. These are people retained by the drug companies to write medical articles. The companies then search for well known academics who may or may not have had anything to do with the original research, who would be willing, for a fee, to sign their names as authors of these articles. David Healy, a psychiatrist from Wales, investigated this phenomenon as it applied to the antidepressant Zoloft ® made by Pfizer, the world’s largest drug company. He compared a series of articles on the drug that were ghost-authored with ones that were not and found that the profile of the former in the medical literature was much higher. He speculates that the profile of the authors found to sign the ghost written pieces may have increased the chances that the articles would appear in more prestigious journals.

Increasing profits by selling more drugs

In a market economy, there are two ways to increase the amount of money you make-price your products higher or sell more of them. The first option is restricted by some form of price controls in virtually every developed country except the U.S. and even there important market segments like the Department of Veterans’ Affairs, have to be offered drugs at steep discounts. The second option, to increase sales volume or at least to sell more higher priced drugs is the path that companies take.

Really superior medications will generally sell themselves (there are sometimes exceptions) as knowledge of them spreads amongst the medical community through journal articles and continuing medical education courses. As we have already seen, there just are not that many of these drugs. So how do the companies try to increase sales of products that are as good as, but no better than, those from the competition? The answer to that question is simple, they spend more money promoting them; usually to doctors but in the United States and New Zealand also increasingly directly to consumers. In fact, in many countries the pharmaceutical industry as a whole spends more on promotion than it does on research and development. In Canada R&D amounts to just over $1.2 (CAN) billion while the figure for promotion is estimated at $1.4 billion.

What does promotion do to prescribing?

What we know about the consequences of spending billions upon billions of dollars on promotion to doctors is not reassuring. Since the early 1970s, there have been over a dozen 10 studies from Belgium, Finland, the Netherlands, the United Kingdom and the United States that have looked at how well doctors prescribe and have correlated that to where they get their information about drugs. In every case, except one, the conclusion has been the same, the more doctors rely on information that they get from the pharmaceutical industry the worse they prescribe.

As any good epidemiologist will tell you, correlations are not the same as cause and effect. However, when you have more than 12 studies telling you one thing and one saying the opposite then you have to start thinking that something is really going on.

The usual reaction from doctors to the results from these studies is “I’m not affected, it’s the person down the hall.� Fair enough, because when you ask doctors what they think about drug company promotion the answer is mostly negative. If you dig a bit deeper though and look at what are the most frequently used information sources, then ones from industry, especially sales representatives, are usually high on the list. Moreover, sometimes doctors may be unaware of being influenced. They say that they go to scientific sources for their information, but when the message about a drug’s safety and effectiveness in scientific and commercial sources differs there are documented cases where doctors side with the message in the advertising.

How many doctors are out there who are negatively influenced by industry? No one really knows exact numbers but academics, the medical profession and especially the industry all know that they exist. Industry argues that it is foolish for doctors to prescribe just on the basis of information in promotion, that doctors should consult other sources. And industry is right, we should. But this is the real world, and in the real world a sizeable number of doctors are foolish and stop looking after they hear what the sales representatives have to say or after they have read the advertising in the journals. Companies know this will happen but they do not take any responsibility. Why? Because if they made their promotion more accurate, more objective, it would affect sales.

Promoting drugs directly to consumers

Before leaving the topic of promotion, just a few words about the phenomenon of direct-to-consumer advertising in the United States. In 2005, a total of $4.2 (US) billion was spent on this type of advertising and the amount is rising yearly. Companies say that its purpose is to make consumers more aware of treatment options and to “empower� them.

If promotion does not help doctors it is unclear how it is going to help consumers but let us leave that aside. What sorts of drugs were companies most interested in informing consumers about in 2004? Out of the top 20 most heavily advertised drugs there were three for erectile dysfunction, two antihistamines and one each for toenail fungus, insomnia and eczema. Granted all these drugs have some value but erectile dysfunction and hay fever and hair loss are not at the top of the list of diseases that medical science is out to conquer. But drugs for these conditions do bring in big sales.

Changing health care priorities

Finally, there is the very real chance that the profit motive is changing some of the fundamental priorities in the way that we look at health care. The pharmaceutical industry is the single largest funder of medical research in the United States and Canada and given the nature of the industry it is primarily product oriented in its research priorities. As scientists increasingly turn to industry for money they will naturally tailor their research interests to fit the goals of the drug companies. There is no point in asking drug companies to fund research into behavioural modification or nondrug therapies for problems such as sexually transmitted diseases. Certain questions will just go unasked; health problems that cannot be solved with patented medications will not be investigated.

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Shedding light on youthful hair loss

July 11, 2006

Q: My 21-year-old granddaughter’s hair is falling out. She doesn’t know what to do. She had blood work done, and the doctor told her that her cholesterol is high. I told her I would write to you for help. I appreciate any help you can give.

Q: I have a 25-year-old grandson who’s losing his hair. What causes this?

A We’d best start with some hairy facts. Nearly 90 percent of the hair on a person’s head is in the growing phase; 10 percent is in a resting stage and destined to soon fall out; 1 percent is in a transition from growing to resting. Every day, normally 100 to 150 hairs fall out. They’re in the resting stage. If you count all the hairs on your brush and comb in one day, you can see if your hair loss deviates from the norm.

A dermatologist can examine the fallen-out hair and determine which stage of its life it’s in. By finding the stage of the shed hair, the doctor can narrow the possible causes of hair loss.

As an example, in the resting phase, a sudden loss of more than 150 hairs in a day can be due to drugs, dieting, thyroid gland abnormalities, surgery in the near past, a recent illness with high fever or pregnancy. This kind of hair loss almost always is restored in a reasonable time span.

Another common cause of hair loss is sensitivity to male hormones. Genes determine at what age it happens. They can cause it to fall out at young ages. It happens to women too. Women make male hormones. In men, the loss begins at the temples and the crown of the head. In women, the hair loss is diffuse. This kind of hair loss might respond to treatment with minoxidil, which can be purchased without a prescription. Propecia is an oral tablet that’s designed for men’s use for male pattern baldness.

If the dermatologist cannot find a treatable cause of hair loss — and that takes a bit of sleuthing — hair transplants are always a possibility.

I would wager that the young woman’s hair loss is the kind due to excessive loss of resting hairs. This is the kind of loss that self-corrects. Her cholesterol has nothing to do with her hair loss. The young man’s is more likely due to sensitivity to male hormones.

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Hair Loss Program: Revolutionary Concept Released; Stop Hair Loss Naturally

July 7, 2006

Leading International hair health specialist, Jonathon E Phillips shows how and why this breakthrough information has never been previously available — revealing how people can stop hair loss naturally and retain healthier, fuller, thicker hair — on his book titled “Hair Loss No More.”

The book “Hair Loss No More” offers step-by-step guidance to vital hair health that will change life forever. A good number of customers are stating similar statements to Robert Kool who said “Hair loss has been the bane of my life for years. I have previously spent thousands of dollars on treatments and so called miracle products all to no avail. Finally at the point of giving up and in total despair I learnt of Jonathon Phillips ‘Hair Loss No More’. The results have been excellent — for the first time in my life I feel in control. My only one complaint is why did I not discover this before wasting so much time, frustration and money.”

From the step-by-step guide people will learn how to prevent and stop hair loss, and restore hair growth. They will also learn how to not only revitalize and restore their hair but also greatly enhance and improve their overall health and longevity. There is no doubt that using the ‘Step-By-Step Hair Power Program’ is the single most important step people could take not only for the sake of their hair but for overall health and well being.

This totally unique breakthrough information has never before been previously available and has been Internationally hailed by medical practitioners both orthodox and alternative. People are advised not to spend one more dollar on hair concerns until they become aware of this breakthrough knowledge.

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President Bush will turn 60 on Thursday

July 5, 2006

The most powerful man in the world turns 60 on Thursday and he just can’t seem to stop talking about it. Barely a week has gone by this year that President Bush has not brought up his advancing age at least once.

“How you doing, sir?� a reporter asked Bush at a news conference a few hours after a middle-of-the-night return from a grueling sprint to Baghdad. “I’m doing all right, thank you,� the president replied. “A little jet lagged, as I’m sure you can imagine. Nearly 60.�

In his State of the Union address, the president referred to his upcoming birthday as “a personal crisis.� It was a laugh line — used to segue to a call for overhauling programs, such as Social Security and Medicare, soon strained by Bush’s baby boomer generation.

In fact, Bush is nearly always cracking wise when the topic of his age comes up. The humor, however, contains unmistakably wistful notes, revealing a president who is least somewhat pensive both about aging and his relevance after he leaves the White House in 31 months.

Bush’s “I’m getting old� preoccupation puts him in good company.

Cher, Bill Clinton, Dolly Parton, Donald Trump, Sylvester Stallone, Diane Keaton, Suzanne Somers, Reggie Jackson and Jimmy Buffet also are turning 60 in 2006. They are part of the first wave of the 78-million strong baby boomers to enter their senior years.

Karl Pillemer, a professor of human development at Cornell University, said the president’s musings are reflective of the group.

Boomers brought advances in the civil rights and women’s rights movements. But the generation also introduced America to what Pillemer called “the new narcissism.� And now, members of this group are presented with a slew of sometimes bewildering roles: seeing their children enter adulthood; contemplating grandparenthood; watching their parents age and die; retiring from work; and dealing with physical and intellectual limitations.

“For many boomers, turning 60 is a fairly significant shock,â€? Pillemer said. “The generation that believed it would be young forever, clearly will not. … The boomers are having a hard time with the existential reality of life not being one open-ended opportunity after another.â€?

Dr. J. Edward Hill, the immediate past president of the American Medical Association and a family physician from Tupelo, Miss., has seen many patients display Bush’s chatty angst. But he said the president’s joshing around is one of the healthiest approaches.

“When you worry about something, you talk about it,� he said. “The stints of humor are critically important.�

In speech after speech, Bush has referred to himself as the “old president — getting older by the minute, by the way“; as one of “the gray-haired folks“; as “getting older“; and as just flat-out “old.�

He often reflects on how he considered 60 practically ancient as a younger man, but has been inspired by changing circumstances to adjust his perspective. “It’s all in your mind,� he said recently in Omaha, Neb. “It’s not that old, it really isn’t.�

“When are you turning 60?� he quizzed Pete Navarro, a somewhat wrinkled Florida man participating with the president on a panel in May on Medicare’s new prescription drug benefit. Bush deflated a bit when Navarro reported that his 60th birthday was not until next January. “Oh, January. You’re a lot younger than I am,� the president said.

Most often, the famously competitive and fitness-crazed president brings up the physical ravages of time. He jokes about losing his hearing (a frequent source of ribbing by his staff as well), about how knee problems turned him to riding his bike after years of jogging, or about how he is too old for the basketball court.

Bush even broods aloud about his life expectancy, estimated to be an additional 19 years for the average American male his age. “I don’t know about you all, I plan on just kind of stretching it out a little bit,� he told GOP donors in Indiana in March.

Like most presidents, Bush has grayer hair, more lines and a few extra pounds than when he took office. Yet he still has the health statistics and energy of a much younger man.

Those close to him say Bush is entirely comfortable with the milestone, in part because of the discipline that allowed him to turn 20 years ago from a life of excessive partying and career meandering and never look back.

He also revels in remaining in shape, even markedly improving his fitness, thanks to intense, six-days-a week workouts. The president may have traded running shoes for a mountain bike, but he pushes himself hard, so much so that he has made news several times when hairpin rides sent him tumbling to the ground.

“I’m sure it makes it easier, especially when you’re whipping people half your age — some of them trained to kill people, like Secret Service agents,� White House counselor Dan Bartlett said.

The president’s most recent physical, conducted last July, found he had a resting heart rate in the range of a well-trained athlete and nothing worse than mild hearing loss, skin lesions from sun damage, occasional acid reflux and joint stiffness. His physicians placed him in a “superior� fitness category for men his age.

Age milestones are common for commanders in chief.

Ten other presidents have turned 60 in office. Dwight Eisenhower had his 70th birthday in the White House, as did Ronald Reagan. Seven others turned 50, including Clinton.

The president’s 60th celebration looks barely different from other recent birthdays, just a bit bigger.

About 150 close friends and family are dining with Bush and his wife, Laura, who turns 60 herself in November, on July 4 in the White House residential quarters. Afterward, they will gather on the Truman Balcony for Washington’s dramatic fireworks show — and no doubt keep Bush from his usual 9 p.m. bedtime in the process.

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And a child shall lead them’

July 3, 2006

That’s bad. Somebody ought to help those poor people. How many times have you said this? How many times have you been that “somebody”? In today’s society, we are so programmed to the hustle and bustle of our ever-so-busy lives that we rarely stop to be that “somebody.”

We can all take a lesson from a brave little 10 year-old girl that has been planning to help someone else since she was in the first grade. Inspired by a cousin in Jackson, Miss. who had done it before her, shy, little Mary Kay Coffee of Selma decided to grow her hair long so that she could donate it to Locks of Love. This is a non-profit organization that provides hairpieces for financially disadvantaged children - 18 years and younger - suffering from long-term medical hair loss. Tracy Thames, at Cuts and Curls on Selma Ave., had the honor of cutting the hair of this admirable little girl.

“She likes the idea of helping other (little girls),” said Mary Kay’s father, Donnie Coffee Jr.

Mary Kay has inspired another person to grow her hair out so that she too can donate to Locks of Love. It is her friend, nine-year-old, Becky Delgado.

“I think other people should have hair just like me,” said Delgado.

According to the Locks of Love website the majority of hair donations come from children wanting to help other children.

” … and a little child shall lead them.” (Isaiah 11:6, KJV)

Locks of Love was started in 1997 by Madonna Coffman who lost her hair to alopecia - a disorder where hair follicles are damaged - after receiving a hepatitis vaccination. Coffman recovered, but 15 years later, her 4-year-old daughter was stricken with alopecia. It was the suffering of her daughter that inspired Coffman to fully commit to Locks of Love. Coffman’s story can be found on the Locks of Love Web site, www.locksoflove.org.

Any one can donate hair to the organization. Your hair must be 10 inches minimum in length. It can be colored or permed, but must not be damaged or bleached. If your hair has been cut years ago, it is still useable as long as it has been stored in a ponytail or braid. If you have curly hair, the hair can be pulled straight to measure the 10 inches. You do not have to go to a hairdresser, but you may opt to do so.

“We didn’t want to butcher it up,” said Donnie Coffee Jr. of he and his wife Amy’s choice to bring Mary Kay to Cuts and Curls.

Anyone can cut your hair as long as the guidelines are followed. The guidelines are listed in full on the website.

These special hairpieces can take between four and six months to reach the recipient. The process requires a mold of the child’s head to be made at home and shipped to Locks of Love where a foam mold is made. The foam mold serves as the head block for the hairpiece. From that foam mold, a “fit cap” is made. That cap is sent back to the child to try on. Once the fit has been approved and skin tone color and hair length have been chosen, the hair is prepared and sent to Indonesia where the hairpieces are manufactured. Each hair is hand inserted into the cap. When finished, the cap will contain 150,000 strands of hair.

Even though Locks of Love provides the hairpieces free of charge, they must pay the manufacturing costs. Each hairpiece retails between $3,500 and $6,000.

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